Peptide modifications

The following is a list of peptide modifications we have performed over the last 12 months.

• Modifications at the N-terminus
• Modifications at the C-terminus
• Unnatural amino acids
• Other peptide modifications

Modifications at the N-terminus

• Acetyl
• Biotin
• Fluorescein (FAM, FITC)
• TAMRA
• Cy dyes (Cy3, Cy5 etc)
• Alexa fluor dyes
• Benzyloxycarbonyl (CBZ) (Z)
• Pyroglutamic acid (Pyr)
• Octanoic acid
• Glycolic acid
• t-butoxycarbonyl (Boc)
• Fluorenylmethoxycarbonyl (Fmoc)
• Rhodamine110
• Benzoic acid
• PEGylation
• Myristic acid

Modifications at the C-terminus

• Alcohol
• Aldehyde
• Amide
• Methyl ester
• Methyl amide
• Ethyl amide
• Biotin (Lys or Cys side chain)
• Benzaldehyde (Lys side chain)
• Fluorescein (Lys side chain)
• TAMRA (Lys side chain)
• Cy dyes (Lys side chain)
• pNA
• Farnesyl (Cys side chain)

Unnatural amino acids

• Acetyl-lysine
• Amino hexanonic acid (Ahx)
• Amino isobutyric acid (Aib)
• Amino benzoic acid
• Beta alanine
• Citrulline (Cit)
• Cyclohexylalanine (Cha)
• Cyclohexylglycine (Chg)
• D amino acids
• Methyl Lysine
• Dimethyl Lysine
• Trimethyl Lysine
• Methyl Arginine
• Dimethyl Arginine (Symmetric)
• Dimethyl Arginine (Asymmetric)
• Isotopically labeled amino acids (D, 13C, 15N)
• Phospho Ser, Thr, Tyr
• Napthylalanine (Nal)
• Gamma amino butyric acid (GABA)
• Indanylglycine
• Hydroxyproline (Hyp)
• N-methyl amino acids
• Norleucine (Nle)
• Norvaline (Nva)
• Fluoro-Phe
• Phenylglycine (Phg)

Other peptide modifications

• Conjugation to KLH, BSA Ova
• Cyclisation (head to tail, side chain, disulfide)
• Peptides anchored to controlled pore glass (CPG)